Greater Manchester

Cardiovascular research domain

The Cardiovascular Domain applies discovery and translational science, and excellence in clinical care, to improve life expectancy for patients with cardiovascular disease in Greater Manchester.

Greater Manchester is one of the largest population catchments for tertiary cardiac services in Europe and offers a unique resource for clinical research. This is also combined with training the next generation of healthcare staff and researchers to the highest standard. Through the strengths and catchment populations of our partners, we will take early discovery and innovation from basic underpinning research into practice, prove effectiveness, and disseminate best practice across our region.

Greater Manchester’s population suffers disproportionately from heart and circulatory disease. Our services include large tertiary cardiac units (Manchester University NHS Foundation Trust) that, together, provide the highest quality specialist care to a population of around 3.5 million people, with additional provision of nationally designated cardiopulmonary transplantation and ventricular assist services to 6.6 million people.

Stroke is a devastating condition affecting people of all ages, causing death and long-term disability. Following changes to GM hospital stroke services in 2015 to ensure patients have access to better quality hospital care and timely specialist treatment, Greater Manchester now has the best scoring hospital stroke pathway in the country, with all stroke patients having access to care rated as ‘A’ (the highest available rating) by The Sentinel Stroke National Audit Programme. Stroke research is an important part of stroke services and a major research strength in Manchester. A wide range of studies involving stroke and the emergency conditions affecting the brain, take place at Salford Royal NHS Foundation Trust.

The University of Manchester’s Division of Cardiovascular Sciences combines clinical, translational and basic science research with the aim of translating our understanding of the cellular and molecular processes underlying cardiovascular disease into improved clinical treatments and patient care.

We focus on three research areas: Hypertension and its consequences; Cardiac physiology and heart failure; and Cardiovascular Genomics. These research strengths are interdisciplinary, feature strong international collaborations and address global cardiovascular health challenges. The university’s Division of Diabetes, Endocrinology and Metabolism comprises internationally leading researchers into endocrine organ development, diabetic complications, the neuronal control of appetite, and circadian clocks in cardiometabolic disease.

In addition, the disease burden on North West England is particularly high for common diseases such as diabetes. Our successful research programmes aim to improve the screening and treatment of this disease.

Achievements:

Pioneering research in Manchester established the role of interleukin-1 in mediating neurological damage  following stroke in animal models, and showed that IL-1 receptor antagonism could reduce damage.

Internationally renowned cellular cardiac physiologists in Manchester are researching basic mechanisms of arrhythmogenesis in animal models and in human tissue samples provided by MAHSC partners.


£10,000 funding awards available for Cardiovascular & Diabetes domain research projects

Researchers within Greater Manchester can apply for £10,000 in funding to support research into cardiovascular disease.

Health Innovation Manchester, through its Manchester Academic Health Science Centre (MAHSC) Cardiovascular Research Domain, is inviting researchers to apply for one of four funding awards.

The awards are designed to fund research-led projects that have potential to generate clinical impact and patient benefit. The projects should focus on cardiovascular disease and its co-morbidities, taking into account the specific health needs of the Greater Manchester area.

Projects may include, but are not limited to:

  • Pilot feasibility studies
  • Projects to develop new technologies or biomarkers to diagnose and treat cardiovascular disease
  • Preventative approaches to improve cardiovascular health.

Awards may fund staff salaries, project running costs and equipment essential to the study/project. Applicants should be working in an established research institution or NHS organisation within the Greater Manchester area. Projects must begin by 30 June 2020. All applications must have the approval of the applicant’s Clinical Director/or Head of Research Centre.

Deadline for submission via email to PMOSupport@healthinnovationmanchester.com (FAO Lorraine Burey), is 15 February 2020.


Meet the Cardiovascular Research Domain Academic and Clinical Leads

Cardiovascular Research Domain Academic Lead Professor Bernard Keavney

Professor Bernard Keavney

Cardiovascular Research Domain Academic Lead and Consultant Cardiologist at Manchester University NHS Foundation Trust

Cardiovascular Research Domain Clinical Lead Dr Jaydeep Sarma

Dr Jaydeep Sarma

Cardiovascular Research Domain Clinical Lead and Consultant Interventional Cardiologist at Manchester University NHS Foundation Trust

Cardiovascular Research Domain Clinical Lead Dr Adrian Parry-Jones

Dr Adrian Parry-Jones

Cardiovascular Research Domain Clinical Lead and Senior Lecturer in Vascular Neurology in the Division of Cardiovascular Sciences at The University of Manchester

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