Greater Manchester, Manchester

Early Detection of Heart Failure

Part of the Health Innovation Accelerator – Advanced Diagnostics Accelerator programme

The Early Detection of Heart Failure project aims to develop a new approach to detecting and treating patients at increased risk of heart failure.

Heart Failure (HF) is an increasingly common condition that causes a person’s heart to become unable to pump blood around the body properly. The disease is an escalating public health problem in the UK, estimated to affect approximately 1-2% of the adult population with data indicating that citizens across Greater Manchester are at a significantly higher risk than other UK areas.

The Early Detection of Heart Failure programme is delivered as part of a series of projects that looks to address Greater Manchester’s major morbidities for the Advanced Diagnostics Accelerator (ADA), part of the Health Innovation Accelerator. The Health Innovation Accelerator has been established to rapidly improve the diagnosis and treatment of disease across the 2.8m Greater Manchester population.

A significant challenge for heart failure treatment is that the condition is currently diagnosed too late. As part of the project, an innovative ‘risk calculator’ solution will be used to identify patients at greatest risk of the disease, before they develop later stages of the disease.

An inclusive engagement strategy is key to this work, as the focus will be on the patients and communities most in need such as those from socio-economically deprived and ethnically diverse backgrounds. The project will assess the uptake of the new ‘risk calculator’ solution to be used within local General Practices (GP) and evaluate the effectiveness of this new way for working.

The project will continue to recruit 600 local people from across Greater Manchester to participate in this research, which will involve attending Wythenshawe Hospital – part of Manchester University NHS Foundation Trust (MFT) – for blood tests and a Cardiac MRI (Magnetic Resonance Imaging). The patient’s health care journey will be monitored for the next 5 years.

The benefits of this work include detecting Heart Failure at an earlier stage, preventing long term ill health and premature death. The project will also calculate the cost saving of the risk calculator for HF if applied on a larger scale. This project will also create the right environment for further collaborative research around heart health moving forward.


The Early Detection of Heart Failure project is delivered by Health Innovation Manchester in partnership with:

Manchester University NHS Foundation Trust (MFT) received a Research Grant from AstraZeneca.

The Health Innovation Accelerator

The Health Innovation Accelerator encompasses two projects, the Advanced Diagnostics Accelerator and the DEVOTE programme, delivered through a partnership between Health Innovation Manchester, Manchester University NHS Foundation Trust (MFT), The University of Manchester, and industry partners.

This project is part-funded by the Greater Manchester Innovation Accelerator programme. Led by Innovate UK on behalf of UK Research and Innovation, the pilot Innovation Accelerators programme is investing £100m in 26 transformative R&D projects to accelerate the growth of three high-potential innovation clusters – Glasgow City Region, Greater Manchester and West Midlands. Supporting the Government’s levelling-up agenda, this is a new model of R&D decision making that empowers local leaders to harness innovation in support of regional economic growth and help attract private R&D investment and develop future technologies.

A graph representing the Health Innovation Accelerator.
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